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Scientist
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Scientist
On-site
Permanent
Cambridge, MA, 02141
49.52 -
54.6
Today
15125114
Copy job link
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LinkedIn
Whatsapp
X (Formerly Twitter)
Facebook
Description
Job title: Scientist
Location: Cambridge, MA
Duration: 12 months
Pay Rate: $49.52-$54.60/hr
100% Onsite
Site Locations: Cambridge
Crossing, MA (CMX)
Work Schedule: 9-5 ET
We are seeking an experienced
individual with cancer research and oncology drug discovery expertise to join
the Discovery Biology team within the Oncology Thematic Research Center in
Cambridge, MA. The qualified candidate is a highly motivated, interactive, and
creative scientist and with the ability to work across a highly matrixed
organization to advance programs from target discovery and validation to lead
optimization, selection of drug candidate and IND-enabling biology related
activities.
This individual will be dedicated
to designing and executing experimental studies related to the decisional
progress of our programs from early stages all the way through IND filling. The
candidate will be involved in executing biology bench studies that will advance
the understanding of mechanism of action as well as developing various cellular
assays to enable compound triaging and identification of potential drug
candidates. In addition, the individual will work closely with other functions,
such as informatics and predictive science, lead discovery and optimization, in
vivo pharmacology, and translational research teams to design/execute work
related to patient stratification, identification of appropriate PD markers and
assay development/transfer for miniaturization, among others.
In the role as a Scientist
within Oncology Discovery Biology, the ideal candidate:
⢠Applies extensive scientific
knowledge and technical skills to conduct molecular and cellular biology
related studies to better understand target and disease biology
⢠Uses current and new
technologies for function-based characterization for small molecule hit
validation, mechanism of action understanding, and compound triaging/ranking
⢠Designs and executes experiments
independently, troubleshoots as needed, interprets and discusses data, with
accurate, timely and detailed record-keeping
⢠Performs laboratory work related
but not limited to 2D/3D/spheroid cell culture and related cellular assays,
Western blot and/or JESS, qRT-PCR, flow cytometry, proliferation and/or
cytotoxicity assays (CyQuant, CTG, apoptosis, IncuCyte, etc.), high-content
imaging (e.g. Phenix), ELISA, MSD and/or HTRF assays, colony formation assay,
processing of DNA/RNA/protein, IP/Co-IP
⢠Generates and characterizes
relevant cell models, such as using genetic tools (CRISPR, shRNA, siRNA,
lentiviral mediated target overexpression, etc.) and establishing
drug-resistant cell lines
⢠Collaborates with rest of
biology team members as well as other functional area leads e.g. pharmacology,
DMPK, informatics and predictive science, etc.
⢠Communicates via email,
meetings, and reports
⢠Makes presentations in small,
multidisciplinary meetings, logically presenting data and interpretation to
convey clear, key messages
Responsibilities will include
but are not limited to the following:
⢠Design and implementation of
high-throughput cell-based reporter assays to characterize drug candidates
⢠Establish stable cell lines via
lentiviral transduction and maintain mammalian cell lines
⢠Conduct routine molecular and
cellular experiments including DNA/RNA/protein extraction, immunoblot analysis,
and immunoprecipitation
⢠Assist senior researchers in
executing, conducting analyses, and reporting results of experiments
⢠Familiarity with literature and
internal best practices to identify opportunities to improve productivity and
quality of work
⢠Analyze, troubleshoot, and
recommend corrective actions for routine problems
⢠Maintain an accurate,
comprehensive, and current laboratory notebook
⢠Write protocols, procedures, and
technical reports
⢠Communicate results via written
reports and oral presentations
Qualifications:
⢠BS with 5+ years of experience
post-graduation or MS.
⢠Expertise in mammalian cell
culture, plate-based cellular assays, immunoblotting, lentiviral infection,
cellular transfection, and basic molecular biology techniques
⢠Experience with medium and
high-throughput screening is highly preferred
⢠Experience with targeted protein
degradation assay is a plus
⢠Familiarity with automation
instruments and multi-mode plate readers
⢠Outstanding problem-solving and
organization skills.
⢠Effective team player and strong
individual contributor
⢠Self-driven, flexible,
pragmatic, and able to handle multiple tasks while delivering high quality data
⢠Effective communication skills,
both verbal and written
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Scientist
Copy job link
Email
LinkedIn
Whatsapp
X (Formerly Twitter)
Facebook
On-site
Permanent
Cambridge, MA, 02141
49.52 -
54.6
Today
15125114
Description
Job title: Scientist
Location: Cambridge, MA
Duration: 12 months
Pay Rate: $49.52-$54.60/hr
100% Onsite
Site Locations: Cambridge
Crossing, MA (CMX)
Work Schedule: 9-5 ET
We are seeking an experienced
individual with cancer research and oncology drug discovery expertise to join
the Discovery Biology team within the Oncology Thematic Research Center in
Cambridge, MA. The qualified candidate is a highly motivated, interactive, and
creative scientist and with the ability to work across a highly matrixed
organization to advance programs from target discovery and validation to lead
optimization, selection of drug candidate and IND-enabling biology related
activities.
This individual will be dedicated
to designing and executing experimental studies related to the decisional
progress of our programs from early stages all the way through IND filling. The
candidate will be involved in executing biology bench studies that will advance
the understanding of mechanism of action as well as developing various cellular
assays to enable compound triaging and identification of potential drug
candidates. In addition, the individual will work closely with other functions,
such as informatics and predictive science, lead discovery and optimization, in
vivo pharmacology, and translational research teams to design/execute work
related to patient stratification, identification of appropriate PD markers and
assay development/transfer for miniaturization, among others.
In the role as a Scientist
within Oncology Discovery Biology, the ideal candidate:
⢠Applies extensive scientific
knowledge and technical skills to conduct molecular and cellular biology
related studies to better understand target and disease biology
⢠Uses current and new
technologies for function-based characterization for small molecule hit
validation, mechanism of action understanding, and compound triaging/ranking
⢠Designs and executes experiments
independently, troubleshoots as needed, interprets and discusses data, with
accurate, timely and detailed record-keeping
⢠Performs laboratory work related
but not limited to 2D/3D/spheroid cell culture and related cellular assays,
Western blot and/or JESS, qRT-PCR, flow cytometry, proliferation and/or
cytotoxicity assays (CyQuant, CTG, apoptosis, IncuCyte, etc.), high-content
imaging (e.g. Phenix), ELISA, MSD and/or HTRF assays, colony formation assay,
processing of DNA/RNA/protein, IP/Co-IP
⢠Generates and characterizes
relevant cell models, such as using genetic tools (CRISPR, shRNA, siRNA,
lentiviral mediated target overexpression, etc.) and establishing
drug-resistant cell lines
⢠Collaborates with rest of
biology team members as well as other functional area leads e.g. pharmacology,
DMPK, informatics and predictive science, etc.
⢠Communicates via email,
meetings, and reports
⢠Makes presentations in small,
multidisciplinary meetings, logically presenting data and interpretation to
convey clear, key messages
Responsibilities will include
but are not limited to the following:
⢠Design and implementation of
high-throughput cell-based reporter assays to characterize drug candidates
⢠Establish stable cell lines via
lentiviral transduction and maintain mammalian cell lines
⢠Conduct routine molecular and
cellular experiments including DNA/RNA/protein extraction, immunoblot analysis,
and immunoprecipitation
⢠Assist senior researchers in
executing, conducting analyses, and reporting results of experiments
⢠Familiarity with literature and
internal best practices to identify opportunities to improve productivity and
quality of work
⢠Analyze, troubleshoot, and
recommend corrective actions for routine problems
⢠Maintain an accurate,
comprehensive, and current laboratory notebook
⢠Write protocols, procedures, and
technical reports
⢠Communicate results via written
reports and oral presentations
Qualifications:
⢠BS with 5+ years of experience
post-graduation or MS.
⢠Expertise in mammalian cell
culture, plate-based cellular assays, immunoblotting, lentiviral infection,
cellular transfection, and basic molecular biology techniques
⢠Experience with medium and
high-throughput screening is highly preferred
⢠Experience with targeted protein
degradation assay is a plus
⢠Familiarity with automation
instruments and multi-mode plate readers
⢠Outstanding problem-solving and
organization skills.
⢠Effective team player and strong
individual contributor
⢠Self-driven, flexible,
pragmatic, and able to handle multiple tasks while delivering high quality data
⢠Effective communication skills,
both verbal and written
Loading...
Link copied successfully!