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    Scientist

    vector fire

    Cambridge, MA, 02141

    $49.52 - $54.6

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    Today

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    $42 - $50

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    $32 - $34

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    Scientist

    building regular On-site briefcase Permanent
    Cambridge, MA, 02141 49.52 - 54.6 Today 15125114

    Description

    Job title: Scientist
    Location: Cambridge, MA
    Duration: 12 months
    Pay Rate: $49.52-$54.60/hr

    100% Onsite
    Site Locations: Cambridge
    Crossing, MA (CMX)
    Work Schedule: 9-5 ET

    We are seeking an experienced
    individual with cancer research and oncology drug discovery expertise to join
    the Discovery Biology team within the Oncology Thematic Research Center in
    Cambridge, MA. The qualified candidate is a highly motivated, interactive, and
    creative scientist and with the ability to work across a highly matrixed
    organization to advance programs from target discovery and validation to lead
    optimization, selection of drug candidate and IND-enabling biology related
    activities.

    This individual will be dedicated
    to designing and executing experimental studies related to the decisional
    progress of our programs from early stages all the way through IND filling. The
    candidate will be involved in executing biology bench studies that will advance
    the understanding of mechanism of action as well as developing various cellular
    assays to enable compound triaging and identification of potential drug
    candidates. In addition, the individual will work closely with other functions,
    such as informatics and predictive science, lead discovery and optimization, in
    vivo pharmacology, and translational research teams to design/execute work
    related to patient stratification, identification of appropriate PD markers and
    assay development/transfer for miniaturization, among others.

    In the role as a Scientist
    within Oncology Discovery Biology, the ideal candidate:
    • Applies extensive scientific
    knowledge and technical skills to conduct molecular and cellular biology
    related studies to better understand target and disease biology
    • Uses current and new
    technologies for function-based characterization for small molecule hit
    validation, mechanism of action understanding, and compound triaging/ranking
    • Designs and executes experiments
    independently, troubleshoots as needed, interprets and discusses data, with
    accurate, timely and detailed record-keeping
    • Performs laboratory work related
    but not limited to 2D/3D/spheroid cell culture and related cellular assays,
    Western blot and/or JESS, qRT-PCR, flow cytometry, proliferation and/or
    cytotoxicity assays (CyQuant, CTG, apoptosis, IncuCyte, etc.), high-content
    imaging (e.g. Phenix), ELISA, MSD and/or HTRF assays, colony formation assay,
    processing of DNA/RNA/protein, IP/Co-IP
    • Generates and characterizes
    relevant cell models, such as using genetic tools (CRISPR, shRNA, siRNA,
    lentiviral mediated target overexpression, etc.) and establishing
    drug-resistant cell lines
    • Collaborates with rest of
    biology team members as well as other functional area leads e.g. pharmacology,
    DMPK, informatics and predictive science, etc.
    • Communicates via email,
    meetings, and reports
    • Makes presentations in small,
    multidisciplinary meetings, logically presenting data and interpretation to
    convey clear, key messages

    Responsibilities will include
    but are not limited to the following:
    • Design and implementation of
    high-throughput cell-based reporter assays to characterize drug candidates
    • Establish stable cell lines via
    lentiviral transduction and maintain mammalian cell lines
    • Conduct routine molecular and
    cellular experiments including DNA/RNA/protein extraction, immunoblot analysis,
    and immunoprecipitation
    • Assist senior researchers in
    executing, conducting analyses, and reporting results of experiments
    • Familiarity with literature and
    internal best practices to identify opportunities to improve productivity and
    quality of work
    • Analyze, troubleshoot, and
    recommend corrective actions for routine problems
    • Maintain an accurate,
    comprehensive, and current laboratory notebook
    • Write protocols, procedures, and
    technical reports
    • Communicate results via written
    reports and oral presentations

    Qualifications:
    • BS with 5+ years of experience
    post-graduation or MS.
    • Expertise in mammalian cell
    culture, plate-based cellular assays, immunoblotting, lentiviral infection,
    cellular transfection, and basic molecular biology techniques
    • Experience with medium and
    high-throughput screening is highly preferred
    • Experience with targeted protein
    degradation assay is a plus
    • Familiarity with automation
    instruments and multi-mode plate readers
    • Outstanding problem-solving and
    organization skills.
    • Effective team player and strong
    individual contributor
    • Self-driven, flexible,
    pragmatic, and able to handle multiple tasks while delivering high quality data
    • Effective communication skills,
    both verbal and written
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    Scientist

    building regular On-site briefcase Permanent
    Cambridge, MA, 02141 49.52 - 54.6 Today 15125114

    Description

    Job title: Scientist
    Location: Cambridge, MA
    Duration: 12 months
    Pay Rate: $49.52-$54.60/hr

    100% Onsite
    Site Locations: Cambridge
    Crossing, MA (CMX)
    Work Schedule: 9-5 ET

    We are seeking an experienced
    individual with cancer research and oncology drug discovery expertise to join
    the Discovery Biology team within the Oncology Thematic Research Center in
    Cambridge, MA. The qualified candidate is a highly motivated, interactive, and
    creative scientist and with the ability to work across a highly matrixed
    organization to advance programs from target discovery and validation to lead
    optimization, selection of drug candidate and IND-enabling biology related
    activities.

    This individual will be dedicated
    to designing and executing experimental studies related to the decisional
    progress of our programs from early stages all the way through IND filling. The
    candidate will be involved in executing biology bench studies that will advance
    the understanding of mechanism of action as well as developing various cellular
    assays to enable compound triaging and identification of potential drug
    candidates. In addition, the individual will work closely with other functions,
    such as informatics and predictive science, lead discovery and optimization, in
    vivo pharmacology, and translational research teams to design/execute work
    related to patient stratification, identification of appropriate PD markers and
    assay development/transfer for miniaturization, among others.

    In the role as a Scientist
    within Oncology Discovery Biology, the ideal candidate:
    • Applies extensive scientific
    knowledge and technical skills to conduct molecular and cellular biology
    related studies to better understand target and disease biology
    • Uses current and new
    technologies for function-based characterization for small molecule hit
    validation, mechanism of action understanding, and compound triaging/ranking
    • Designs and executes experiments
    independently, troubleshoots as needed, interprets and discusses data, with
    accurate, timely and detailed record-keeping
    • Performs laboratory work related
    but not limited to 2D/3D/spheroid cell culture and related cellular assays,
    Western blot and/or JESS, qRT-PCR, flow cytometry, proliferation and/or
    cytotoxicity assays (CyQuant, CTG, apoptosis, IncuCyte, etc.), high-content
    imaging (e.g. Phenix), ELISA, MSD and/or HTRF assays, colony formation assay,
    processing of DNA/RNA/protein, IP/Co-IP
    • Generates and characterizes
    relevant cell models, such as using genetic tools (CRISPR, shRNA, siRNA,
    lentiviral mediated target overexpression, etc.) and establishing
    drug-resistant cell lines
    • Collaborates with rest of
    biology team members as well as other functional area leads e.g. pharmacology,
    DMPK, informatics and predictive science, etc.
    • Communicates via email,
    meetings, and reports
    • Makes presentations in small,
    multidisciplinary meetings, logically presenting data and interpretation to
    convey clear, key messages

    Responsibilities will include
    but are not limited to the following:
    • Design and implementation of
    high-throughput cell-based reporter assays to characterize drug candidates
    • Establish stable cell lines via
    lentiviral transduction and maintain mammalian cell lines
    • Conduct routine molecular and
    cellular experiments including DNA/RNA/protein extraction, immunoblot analysis,
    and immunoprecipitation
    • Assist senior researchers in
    executing, conducting analyses, and reporting results of experiments
    • Familiarity with literature and
    internal best practices to identify opportunities to improve productivity and
    quality of work
    • Analyze, troubleshoot, and
    recommend corrective actions for routine problems
    • Maintain an accurate,
    comprehensive, and current laboratory notebook
    • Write protocols, procedures, and
    technical reports
    • Communicate results via written
    reports and oral presentations

    Qualifications:
    • BS with 5+ years of experience
    post-graduation or MS.
    • Expertise in mammalian cell
    culture, plate-based cellular assays, immunoblotting, lentiviral infection,
    cellular transfection, and basic molecular biology techniques
    • Experience with medium and
    high-throughput screening is highly preferred
    • Experience with targeted protein
    degradation assay is a plus
    • Familiarity with automation
    instruments and multi-mode plate readers
    • Outstanding problem-solving and
    organization skills.
    • Effective team player and strong
    individual contributor
    • Self-driven, flexible,
    pragmatic, and able to handle multiple tasks while delivering high quality data
    • Effective communication skills,
    both verbal and written
    Loading...